Do de nola make you lose weight? What does De-Nol help with: instructions and reviews

De-nol is used as a gastroprotective and antiulcer agent.

This is a rather interesting drug: unlike other antiulcer drugs (proton pump inhibitors or H2-histamine receptors), de-nol also has bactericidal activity against Helicobacter, as well as an astringent and anti-inflammatory effect. The active ingredient of de-nol is bismuth tripotassium dicitrate. Once in the acidic environment of the stomach, this substance precipitates with the formation of two insoluble compounds: bismuth oxychloride and bismuth citrate, which, interacting with the protein substrate, form a protective film on the surface of erosive and ulcerative lesions. This polymerglycoprotein film, to a greater extent than normally secreted mucus, protects the gastric mucosa from the effects of hydrochloric acid, bile salts and pepsin. Visually, it looks like a white foamy coating that covers the entire ulcerative surface and persists for several hours.

In addition to the above, de-nol has a whole scattering beneficial properties. It promotes the accumulation of epidermal growth factor (a protein involved in cell growth and differentiation) in the affected area, reduces the activity of digestive enzymes, stimulates the synthesis of prostaglandin E2, which increases mucus formation and alkaline secretion, improves the physicochemical characteristics of gastric mucus, coagulates proteins and destroys Helicobacter.

Taken together, this entire biochemical “mosaic” leads to the desired therapeutic result: under the influence of de-nol, ulcers heal, the protective functions of the gastric mucosa are restored, and the likelihood of recurrence of gastric and duodenal ulcers is reduced. When taking de-nol in the “solo” mode, Helicobacter eradication is successful in 30% of cases, in combination with antibacterial drugs (metronidazole, amoxicillin) - in 90%.

De-nol is available only in tablets; the single recommended dose for adults and children under 12 years of age is 120 mg, taken 4 times a day (as an option - 240 mg 2 times a day). Children 8-12 years old take de-nol 120 mg twice a day. For children 4-8 years old, the drug is prescribed depending on body weight: 8 mcg per 1 kg per day with the same two-time dose. For half an hour after taking de-nol, it is recommended not to drink drinks (including milk, fruit juices), fruits, solid foods, or drugs that reduce stomach acidity. You should not panic if the stool turns black after taking de-nol: this is normal for bismuth preparations. The duration of the course of treatment is 4-8 weeks, then a break is taken for 8 weeks, after which the course can be repeated.

Pharmacology

Antiulcer drug with bactericidal activity against Helicobacter pylori. It also has anti-inflammatory and astringent effects. IN acidic environment In the stomach, insoluble bismuth oxychloride and citrate are deposited, and chelate compounds are formed with the protein substrate in the form of a protective film on the surface of ulcers and erosions. By increasing the synthesis of prostaglandin E, mucus formation and bicarbonate secretion, it stimulates the activity of cytoprotective mechanisms, increases the resistance of the gastrointestinal mucosa to the effects of pepsin, hydrochloric acid, enzymes and bile salts. Leads to the accumulation of epidermal growth factor in the defect area. Reduces the activity of pepsin and pepsinogen.

Pharmacokinetics

Suction and distribution

Bismuth tripotassium dicitrate is practically not absorbed from the gastrointestinal tract.

Removal

It is excreted mainly in feces. A small amount of bismuth entering the plasma is excreted by the kidneys.

Release form

Creamy white, round, biconvex film-coated tablets with "gbr 152" embossed on one side and a square graphic with broken sides and rounded corners embossed on the other side, odorless or with a slight odor. ammonia.

Excipients: corn starch - 70.6 mg, povidone K30 - 17.7 mg, potassium polyacrylate - 23.6 mg, macrogol 6000 - 6 mg, magnesium stearate - 2 mg.

Shell composition: opadry OY-S-7366 (hypromellose 5 mPa×s - 3.2 mg, macrogol 6000 - 1.1 mg).

8 pcs. - blisters (7) - cardboard packs.
8 pcs. - blisters (14) - cardboard packs.

Dosage

For adults and children over 12 years of age, the drug is prescribed 1 tablet. 4 times a day 30 minutes before meals and at night or 2 tablets. 2 times/day 30 minutes before meals.

Children aged 8 to 12 years are prescribed 1 tablet. 2 times/day 30 minutes before meals.

Children aged 4 to 8 years are prescribed a dose of 8 mg/kg/day; Depending on the child’s body weight, 1-2 tablets per day are prescribed (respectively, in 1-2 doses per day). In this case, the daily dose should be as close as possible to the calculated dose (8 mg/kg/day).

The tablets are taken 30 minutes before meals with a small amount of water.

The duration of treatment is 4-8 weeks. You should not take medications containing bismuth for the next 8 weeks.

To eradicate Helicobacter pylori, it is advisable to use De-Nol in combination with antibacterial drugs with anti-Helicobacter activity.

Overdose

Symptoms: with long-term use in doses exceeding the recommended ones, renal function may be impaired (completely reversible when the drug is discontinued).

Treatment: gastric lavage, administration of activated charcoal and saline laxatives. Subsequently, symptomatic therapy is carried out. In cases of renal dysfunction accompanied by high level bismuth in the blood plasma, chelating agents (D-penicillamine, unithiol) can be administered. In case of severe renal dysfunction, hemodialysis is indicated.

Interaction

When taking other medications, as well as food and liquid, in particular antacids, milk, fruits and fruit juices, the effectiveness of De-Nol may change (it is not recommended to take it orally within 30 minutes before and after taking De-Nol).

The combined use of De-nol with tetracyclines reduces the absorption of the latter.

Side effects

From the outside digestive system: Possible nausea, vomiting, increased bowel movements, constipation. These effects are not harmful to health and are temporary.

Allergic reactions: skin rash, skin itching.

From the side of the central nervous system: with long-term use in high doses - encephalopathy associated with the accumulation of bismuth in the central nervous system.

Indications

• peptic ulcer of the stomach and duodenum in the acute phase (including those associated with Helicobacter pylori);
• chronic gastritis and gastroduodenitis in the acute phase (including those associated with Helicobacter pylori);
• irritable bowel syndrome, which occurs predominantly with symptoms of diarrhea;
• functional dyspepsia not associated with organic gastrointestinal diseases.

During treatment with De-Nol, you should not use other drugs containing bismuth.

At the end of a course of treatment with the drug in recommended doses, the concentration active substance in blood plasma does not exceed 3-58 mcg/l, and intoxication is observed only at a concentration of more than 100 mcg/l.

When using De-Nol, stool may turn black due to the formation of bismuth sulfide. Sometimes there is a slight darkening of the tongue.

Impact on the ability to drive vehicles and operate machinery

There is no data on the effect of the drug De-nol ® on the ability to drive vehicles and machines.

Various pathologies of the digestive system are now becoming more common. People consult a doctor with complaints of pain or a feeling of heaviness in the abdomen, flatulence, nausea or intestinal upset. Depending on the symptoms and diagnosis, doctors prescribe different medications. Often, complex treatment includes the drug "De-Nol". Reviews of this remedy note that treatment with it quickly helps improve the functioning of the digestive system and relieve pain.

general characteristics

One of the drugs that most often form the basis for the treatment of stomach ulcers and gastritis in acute or chronic form is De-Nol. Reviews note that this remedy effectively relieves pain and protects the mucous membrane from the effects of aggressive acids in the digestive juice. The drug is available in tablets. They are round, biconvex, covered with a film shell. The tablet is engraved with gbr 152. This is necessary to protect the drug from counterfeiting.

De-Nol is produced by the famous pharmaceutical company Astellas from the Netherlands. On sale you can find packages of 56 or 112 tablets. Reviews of the price of "De-Nola" note that it is quite expensive for some patients. A small package can be bought for 500-600 rubles, but it is usually not enough for a course of treatment. The drug is an over-the-counter drug and is freely sold in any pharmacy.

This medicine is characterized by the fact that when it enters the digestive tract, it interacts with water and turns into a colloidal solution that protects the mucous membrane. Its effect is manifested not only in the stomach, but throughout the intestines. Its components are not absorbed into the blood, but are excreted in the feces.

What's included

The main component of the medicine is bismuth tripotassium dicitrate. Each tablet contains 120 mcg. The drug in the stomach interacts with water and creates a colloidal solution that penetrates deeply into the mucus that envelops the walls of the stomach. The substances contained in this solution protect the mucous membrane. Their maximum concentration is observed on the surface of ulcers and erosions. By binding to proteins, substances colloidal solution create a protective film.

To bind and uniformly distribute bismuth tripotassium dicitrate, auxiliary components have been added to the tablet. These are magnesium stearate, corn starch, povidone and polacriline potassium. The film shell consists of macrogol and hypromellose.

What effect does the drug have?

"De-Nol" is a product from the group of antacids and adsorbents. But it also has anti-inflammatory, gastroprotective and antibacterial properties. The drug is especially effective against Helicobacter pylori. It has been proven that the presence of this microorganism in the digestive tract causes many stomach pathologies. The active substance of the drug penetrates the cell membrane of bacteria, making it permeable. This leads to a decrease in the activity of pathogenic microorganisms and to their rapid death. Helicobacter pylori is especially often found in patients with gastritis and ulcers. The drug in question is effective against any of its strains. But it is best to use it in conjunction with antibacterial drugs. Basically, a combination of De-Nol, Metronidazole and Amoxicillin is prescribed.

Bismuth preparations are effective at any stage of peptic ulcer disease. The main effect of the medication is that it creates a protective film on the surface of the gastric mucosa. This stops the progression of the ulcer and promotes its healing. This film hardly forms on areas of healthy mucous membrane, so it does not interfere with the digestion process at all.

Doctors in reviews of "De-Nol" note its gastroprotective effect. Even in the absence of ulcers and erosions, the drug is effective. After all, it helps to inactivate pepsin and reduce the activity of hydrochloric acid, which irritates the inflamed mucosa. This drug also improves blood supply to the walls of the stomach and intestines and accelerates cell regeneration processes. When taking De-Nol, the gastrointestinal mucosa becomes more resistant to the action of gastric juice, bile acids, pepsin and aggressive enzymes.

When to use

"De-Nol" is often prescribed for various diseases digestive organs. It can be used both as part of complex treatment and independently. Even to prevent exacerbations, De-Nol is prescribed. In reviews of the use of this drug, patients note that it is effective in the following cases:

• Chronic gastritis or gastroduodenitis.
• Atrophic gastritis.
• Inflammatory diseases of the stomach during exacerbation.
• Pathologies caused by Helicobacter pylori infection.
• Exacerbation of stomach or duodenal ulcers.
• Irritable bowel syndrome.
• Gastrophageal reflux disease.
• Dyspepsia not caused by organic diseases.

In addition, there are some conditions that are not listed in the instructions for De-Nol. Reviews from doctors and patients note that the drug can be used for abdominal pain caused by long-term use of anti-inflammatory drugs or alcohol intoxication. Taking "De-Nol" turned out to be effective in the complex treatment of biliary-dependent pancreatitis and flatulence. The drug is also used after gastric surgery to prevent relapses.

Contraindications

Despite the fact that bismuth is not absorbed into the blood, but, after passing through the intestines, is excreted from the body, this medicine cannot be taken by everyone. There are certain contraindications for it, which should definitely be taken into account when choosing treatment methods. This product should not be used if you are hypersensitive or have allergic reactions after taking it. In addition, this medicine is not prescribed during pregnancy and lactation, since bismuth is a heavy metal, it can have a negative effect on the child’s nervous system, penetrating the placenta and into breast milk,

It is not recommended for children under 14 years of age to take it due to the imperfections of their gastrointestinal tract. Sometimes it is possible to use "De-Nol" from 4 years of age, but under the supervision of a doctor and with strict adherence to a special dosage. Contraindications to taking the drug are also impaired renal or liver function. You cannot take De-Nol if you have been treated with other bismuth-based medications within 2 months before. In this case, a serious overdose is possible, as noted by doctors.

"De-Nol": side effects

In most cases, this remedy is well tolerated. If you use it as prescribed by a doctor, and taking into account all contraindications, the treatment will bring relief. However, there are reviews from doctors about the side effects of De-Nol. The most common unwanted reactions of the body are:

• Nausea, vomiting.
• Frequent urge to defecate, followed by constipation.
• Flatulence.
• Decreased appetite.
• The appearance of a metallic taste, darkening of the tongue.
• Allergic reactions, expressed in the appearance of rashes and skin itching.

These reactions are not dangerous and disappear quickly after discontinuation of the drug.

In addition, darkening of the stool and urine is possible during treatment, which is due to the nature of the drug. Patients mention this reaction of the body to these tablets in reviews, adding that it does not cause much discomfort.

Reviews of "De-Nol" note that serious side effects can only occur with an overdose or long-term use of the drug. This is due to the accumulation of bismuth in the body and poisoning with it. Most of all, this substance accumulates in nerve cells, which threatens the development of encephalopathy. But an overdose can also lead to the development of arthralgia, gingivitis, and impaired renal function.

"De-Nol": instructions for use

Reviews about the price of the drug note that treatment with it is quite expensive for some. After all, a full course of “De-Nola” will cost at least a thousand rubles. And it is usually used as part of complex therapy. The dosage and duration of use are selected in accordance with the severity of the pathology and the patient’s health characteristics. In general, opinions about the high effectiveness of the drug outweigh the number of unfavorable reviews about the price.

Instructions for use of "De-Nol" recommend taking 4 tablets per day. This amount is divided into 2 or 4 doses at approximately equal intervals. It is usually recommended to drink the drug 30 minutes before meals three times a day. The fourth dose is best taken before bed, 2 hours after dinner. When taking twice a day, you need to maintain a 12-hour break, that is, take 2 tablets in the morning and in the evening.

The De-Nola tablet must be swallowed whole, without breaking or chewing. You need to drink enough clean water- no less than a glass. Food and other medications should be taken within 30 minutes of taking this medication.

The duration of therapy with De-Nol depends on the severity of the disease, the individual characteristics of the patient, and the therapeutic effect provided. It is usually recommended to take the drug for 1 to 2 months. If it is necessary to repeat the course of therapy, it can be carried out only after 2-3 months to avoid an overdose of bismuth.

The dosage for children under 14 years of age is calculated differently. If, according to doctor's indications, a child aged 8-14 years needs to take the drug, the dosage is reduced by half. Give 1 tablet twice a day. Sometimes the drug is used to treat children over younger age. In this case, the dosage is calculated based on body weight. It is allowed to use "De-Nol" only after 4 years (4 mg for each kg of the child's weight). This is about half a tablet 1-2 times a day. Children need to grind the drug into powder and dissolve it in water.

Special instructions for taking the drug

Most effective treatment will happen if De-Nol is used together with other drugs. Reviews note that it works better against the bacterium Helicobacter pylori in combination with antibiotics. In addition, it is recommended to take other medications prescribed by your doctor. Most often, antibiotics are prescribed together with this drug: Metronidazole, Furazolidone, Amoxicillin, Clarithromycin. For complex treatment, doctors prescribe Phosphalugel, Ranitidine, Kvamatel or Omeprazole.

But "De-Nol" is not combined with all drugs when taken simultaneously. It is especially not recommended to combine it with antacids, as these drugs reduce its effectiveness. "De-Nol" slows down the absorption of tetracycline antibiotics. This drug is often prescribed with proton pump inhibitors, which reduce acidity. The interval between taking them should be at least 30 minutes.

It is prohibited to take any analogues of “De-Nol” at the same time. Reviews from doctors note that in this case there is an overdose of bismuth and its accumulation in the nervous tissue and blood. It is advisable to take the drug separately from meals, preferably half an hour before meals. Otherwise, the main active ingredient will not be able to have a protective effect on the mucous membrane, as it will be mixed with food. You can only drink it with water; it is forbidden to use juices or dairy products for this. In addition, during treatment it is forbidden to drink alcohol, which reduces the effectiveness of the drug.

Analogues

This product is produced by a famous Dutch pharmaceutical company. Despite the fact that in last years packaging takes place in Russia, the cost of the drug for many patients is high. There are analogues of De-Nol on the pharmaceutical market. Reviews of the price of these drugs note that they are more accessible to a wide range of consumers. The composition of these drugs is completely similar, the main active ingredient is the same, so the effect is the same. The following analogues of "De-Nola" are most often used:

• "Ulkavis" - a package of 112 tablets costs 600-700 rubles;
• "Novobimol" - tablets for an entire course of treatment can be purchased for 600 rubles;
• "Escape" is a drug Russian production, but also quite expensive (about 800 rubles for 112 tablets).

There is another remedy that is prescribed in the same cases as De-Nol. This is Venter. Its composition is slightly different. The main active ingredient in it is sucraphalt, a substance made from aluminum salts. It also effectively protects the mucous membrane and binds fatty acids. But this remedy does not destroy Helicobacter pylori.

The drug De-Nol is considered one of the most powerful medications for destroying the Helicobacter pylori bacterium.

It is able to heal damaged walls and reduce the inflammatory process.

De-Nol helps strengthen local immunity and form a protective shell on the damaged wall. It is thanks to this film that protection against hydrochloric acid, enzymes and bile salts occurs.

At correct use it is not absorbed into the inner lining of the gastrointestinal tract.

But if an overdose of De-Nol occurs and side effects appear, then you need to know how to deal with it.

The instructions for use of the drug indicate quite difficultly how to take the drug and what it is made of.

The main active ingredient is called bismuth, but its overdose and side effects can lead to negative consequences, if you take a large dosage per day or at a time, or increase the course of treatment on your own, then intoxication of the body may occur.

Find out also about De-nol, doctors' reviews and side effects.

How does this happen

Taking the drug in more than necessary may lead to symptoms of poisoning.

For example, dysfunction of the gastrointestinal tract may occur.

Additionally on the mucous membrane oral cavity and rashes appear on the body. An inflammatory process also appears in the gastric mucosa.

But bismuth poisoning can be determined by signs such as the fact that the gums will turn black rather than red.

With prolonged overdose, renal dysfunction may occur, and these consequences may be irreparable.

Effect on micro and macroorganisms

The effect of the drug is manifested in the form of the formation of a protective membrane on the inner wall of the stomach and helps eliminate the Helicobacter pylori bacterium.

What effects occur when De-Nol enters the stomach:

1. The acid-base balance is normalized.
2. Bismuth, entering the area of ​​the stomach or duodenum, contributes to the appearance of a protective film. It is this that prevents further destruction and damage.
3. The activity of pepsin, which contributes to the destruction of the gastric mucosa, decreases.
4. Metabolic processes and cell regeneration are accelerated. Additionally, blood circulation in the stomach area improves.
5. Strengthening immunity. The main cause of this disease is the presence of the bacterium Helicobacter pylori. If the body's protective properties are weakened, they penetrate even into the deep parts and tissues of the stomach.

Bacterial gastritis develops first, and then erosions and ulcers appear. Gradually, serious complications can arise. The most dangerous thing that can happen is the appearance of cancer.

It is necessary to take De-Nol for the following diseases:

1. Duodenitis. Chronic or acute.
2. Acute or chronic gastritis.
3. Acute erosive damage.
4. Chronic or acute gastritis.
5. Irritable bowel syndrome. The stool alternates: either diarrhea or constipation.

Features of use

You must take the tablets for 2 months. You should not take more than 4 tablets per day per day. For children, no more than 2 tablets should be taken.

Additionally, it is advisable to stop taking other medications that contain bismuth.

The medicine works cumulatively in the body, so it is advisable that at the end of therapy there should be no more than 58 mg of bismuth per liter of blood in the blood.

An overdose is considered to be 100 milligrams per 1 liter of blood.

Antibacterial action

1. The cell wall of the Helicobacter pylori bacterium is destroyed.
2. The processes in the cytoplasm of the bacterium are disrupted, which gradually leads to its gradual death.

De-Nol is able to penetrate and restore the deep layers of the stomach. The drug does not lead to addiction.

What contraindications does De-Nol have?

Every medicine cures something, and at the same time cripples something. There are contraindications for taking De-Nol.

1. Individual negative reaction to the components of the drug.
2. Acute or chronic renal failure. Disorders of the urinary system.
3. Lactation. Negative Impact occurs on the nervous system and urinary system of the child’s internal organs and is transmitted through milk.
4. Use of other drugs that contain bismuth.
5. During pregnancy. The child may be born with serious pathologies.
6. Little children.

Use with other drugs

It is necessary to stop using other drugs if possible. IN as a last resort, at least 2 hours should pass between taking medications.

It is also necessary to avoid taking milk or fruit while using De-Nol.

Interaction

If De-Nol is used together with tetracycline, the latter is absorbed much less. If it is taken together with Vikalin, Roter and Vikair, the amount of bismuth in the blood increases sharply.

Side effects and contraindications:

• Central nervous system– insomnia, toxic encelophopathy or vegetative-vascular dystonia. These disorders occur with chronic overdose.
• Disorders of the gastrointestinal tract - the tongue becomes black, as do the gums. Vomiting and nausea, disturbances in the functioning of the gastrointestinal tract appear. Black feces
• Allergic reaction – dermatitis and urticaria. Rashes on the skin and mucous membranes.

Side symptoms of overdose

Side effects from the drug lead to chronic disorders:

1. Kidney disorder - acute symptoms insufficiency. Additionally, there is an increase in blood waste, hypertension, and skin itching.
2. Brain dysfunction - at first it may be insomnia, weakness, intoxication.
3. Chronic disorders in the gastrointestinal tract - black gums, pain, vomiting, which occurs once or is repeated over a certain period of time.

What to do before an overdose of De-Nol

It all depends on the degree of poisoning. In severe cases of intoxication, it is necessary to cleanse the body, restore the functioning of the gastrointestinal tract, and normalize the functioning of the kidneys and central nervous system.

In case of urgent need, you need to connect an “artificial kidney” device.

For acute emergency care you need to do the following: First of all, you should call an ambulance. Next, you should rinse your stomach to remove bismuth from the body.

Take sorbents such as activated carbon and saline laxatives. In order to completely remove all bismuth from the body, it takes at least two months.

During this time, taking De-Nol or other similar drugs is prohibited. These are contraindications for use.

Despite the fact that the drug can be purchased at any pharmacy without a prescription, it should be taken only as prescribed by a doctor. It is also important to ensure that the drug is out of the reach of children.

If symptoms of overdose occur, it is necessary to help the body remove bismuth from the body quickly.

If you have the following symptoms, take immediate action:

1. Allergic reaction. Rash or itching on the skin. Attacks of suffocation.
2. Circulatory problems in the head, dizziness, headaches. Problems with memory and attention. Increased nervousness.
3. The chair is accompanied by problems. Some people experience constipation, others have diarrhea. Color feces the tongue and gums change and become black. You may feel nauseous.

Using De-Nol with alcohol

When drinking alcoholic beverages, the protective properties of the stomach are reduced. The secretion of hydrochloric acid increases and the release of mucin and hydrochloric acid is blocked.

You should not drink alcohol while treating the gastrointestinal tract and taking De-nol.

It leads to a decrease in the therapeutic effect of De-Nol, but also increases the risk of bismuth accumulation in the body and intoxication.

Dosage of the drug

Depending on the age of the patient, a certain dosage is prescribed. Children are prescribed 2 tablets per day.

One tablet in the morning, second in the evening. It must be taken 30 minutes before meals.

Teenagers and adults should take no more than 4 tablets per day. At the pharmacy, De-Nol is sold in the form of blisters containing 8 tablets.

When eliminating the symptoms of gastritis, you must stop taking the drug. For some people this happens after 4 weeks, for others - after two months.

Afterwards you need to take a break for 8 weeks. During this time, you should avoid not only De-Nol, but also other drugs containing bismuth.

Nuances when using

There are some rules and nuances that are worth paying attention to. For example, Bismuth, which is the main ingredient in DeNol, causes stool to turn black.

In this case, you should urgently consult a doctor.

Within half an hour you must stop drinking milk and other medications. The problem is that De-Nol requires copious amounts of gastric juice.

In the presence of vegetative-vascular dystonia, it is necessary to limit the time of use of the drug. If you follow the rules for using medications, the likelihood of an overdose is very minimal.

Analogues of De-Nol

Taking the drug for two months is necessary to complete the course of treatment. But this drug is considered expensive, and it can be replaced with cheaper analogues.

For example, Novobismol, Ventrisol, Bismuth tripotassium dicitrate.

Conclusion

If you have diseases of the gastrointestinal tract, you should consult a gastroenterologist. An excellent option would be to take De-Nol.

But you must take it following the instructions. You should not take more than 4 tablets per day for adults and 2 tablets for children.

Useful video

Composition and release form

8 pcs in blister; There are 7 or 14 blisters in a box.

blister 8, cardboard pack 7,

Description of the dosage form

Round, biconvex, film-coated tablets, creamy white, embossed with "gbr 152" on one side and a square graphic with broken sides and rounded corners on the other, odorless or with a slight ammonia odor.

Characteristic

Bismuth preparation.

pharmachologic effect

pharmachologic effect- antibacterial, gastroprotective, antiulcer.

Pharmacodynamics

Antiulcer agent with bactericidal activity against Helicobacter pylori. It also has anti-inflammatory and astringent effects. In the acidic environment of the stomach, insoluble bismuth oxychloride and citrate are precipitated, and chelate compounds are formed with the protein substrate in the form of a protective film on the surface of ulcers and erosions. By increasing the synthesis of PGE, mucus formation and bicarbonate secretion, it stimulates the activity of cytoprotective mechanisms, increases the resistance of the gastrointestinal mucosa to the effects of pepsin, hydrochloric acid, enzymes and bile salts. Leads to the accumulation of epidermal growth factor in the defect area. Reduces the activity of pepsin and pepsinogen.

Pharmacokinetics

Bismuth subcitrate is practically not absorbed from the gastrointestinal tract. It is excreted mainly in feces. A small amount of bismuth entering the plasma is excreted from the body by the kidneys.

Indications of the drug De-Nol ®

peptic ulcer of the stomach and duodenum in the acute phase, incl. associated with Helicobacter pylori;

chronic gastritis and gastroduodenitis in the acute phase, incl. associated with Helicobacter pylori;

irritable bowel syndrome, which occurs predominantly with symptoms of diarrhea;

functional dyspepsia not associated with organic gastrointestinal diseases.

Contraindications

individual intolerance to the drug;

severe renal dysfunction;

pregnancy;

breastfeeding period.

Use during pregnancy and breastfeeding

Contraindicated during pregnancy. Breastfeeding should be stopped during treatment.

Side effects

From the digestive system: Nausea, vomiting, more frequent bowel movements, and constipation may occur. These phenomena are not dangerous to health and are temporary.

Allergic reactions: skin rash, skin itching.

With long-term use in high doses, encephalopathy associated with the accumulation of bismuth in the central nervous system.

Interaction

For half an hour before and after taking De-Nol ®, it is not recommended to take other drugs internally, as well as take food and liquids, in particular antacids, milk, fruits and fruit juices. This is due to the fact that when taken orally simultaneously, they can affect the effectiveness of De-Nol ®.

Directions for use and doses

Inside, with a small amount of water.

Adults and children over 12 years old - 1 tablet. 4 times a day 30 minutes before meals and at night or 2 tablets. 2 times a day 30 minutes before meals.

Children from 8 to 12 years old - 1 tablet. 2 times a day 30 minutes before meals.

Children from 4 to 8 years old - at a dose of 8 mg/kg/day; The daily dosage is divided into 2 doses. Take 30 minutes before meals.

The duration of treatment is 4-8 weeks. Over the next 8 weeks, you should not use medications containing bismuth.

For eradication Helicobacter pylori It is advisable to use De-Nol ® in combination with other antibacterial agents that have anti-Helicobacter activity.

Overdose

Symptoms(with long-term use of doses exceeding the recommended): impaired renal function. These symptoms are completely reversible when De-Nol ® is discontinued.

Treatment: gastric lavage, administration of activated charcoal and saline laxatives. Further treatment should be symptomatic. In case of impaired renal function, accompanied by a high level of bismuth in the blood plasma, the use of complexing agents - dimercaptosuccinic and dimercaptopropanesulfonic acids. In case of severe renal dysfunction, hemodialysis is indicated.

special instructions

The drug should not be used for more than 8 weeks. It is also not recommended to exceed the established daily doses for adults and children during treatment. During treatment with De-Nol ® you should not use other drugs containing bismuth. At the end of a course of treatment with the drug in recommended doses, the concentration of the active substance in the blood plasma does not exceed 3-58 mcg/l, and intoxication is observed only at concentrations above 100 mcg/l.

When using De-Nol ®, stool may turn dark due to the formation of bismuth sulfide. Sometimes there is a slight darkening of the tongue.

Storage conditions for the drug De-Nol ®

At a temperature not exceeding 25 °C.

Keep out of the reach of children.

Shelf life of the drug De-Nol ®

4 years.

Do not use after the expiration date stated on the package.

Synonyms of nosological groups

Category ICD-10	Synonyms of diseases according to ICD-10
K25 Stomach ulcer	Helicobacter pylori
	Pain syndrome with gastric ulcer
	Inflammation of the gastric mucosa
	Inflammation of the gastrointestinal mucosa
	Benign gastric ulcer
	Exacerbation of peptic ulcer
	Exacerbation of gastric ulcer
	Organic gastrointestinal disease
	Postoperative gastric ulcer
	Ulcer recurrence
	Symptomatic stomach ulcers
	Helicobacteriosis
	Chronic inflammatory disease of the upper gastrointestinal tract associated with Helicobacter pylori
	Erosive and ulcerative lesions of the stomach
	Erosive lesions of the stomach
	Erosion of the gastric mucosa
	Peptic ulcer
	Stomach ulcer
	Gastric ulcer
	Ulcerative lesions of the stomach
K26 Duodenal ulcer	Pain syndrome in duodenal ulcer
	Pain syndrome in gastric and duodenal ulcers
	Disease of the stomach and duodenum associated with Helicobacter pylori
	Exacerbation of peptic ulcer
	Exacerbation of duodenal ulcer
	Peptic ulcer of the stomach and duodenum
	Recurrence of duodenal ulcer
	Symptomatic ulcers of the stomach and duodenum
	Helicobacteriosis
	Helicobacter pylori eradication
	Erosive and ulcerative lesions of the duodenum
	Erosive and ulcerative lesions of the duodenum associated with Helicobacter pylori
	Erosive lesions of the duodenum
	Duodenal ulcer
	Ulcerative lesions of the duodenum
K29 Gastritis and duodenitis	Duodenitis
	Exacerbation of gastroduodenitis against the background of peptic ulcer
K30 Dyspepsia	Fermentative dyspepsia
	Hyperacid dyspepsia
	Putrid dyspepsia
	Dyspepsia
	Dyspepsia
	Dyspepsia of nervous origin
	Dyspepsia in pregnant women
	Fermentative dyspepsia
	Putrefactive dyspepsia
	Drug-induced dyspepsia
	Dyspepsia caused by diseases of the gastrointestinal tract
	Dyspepsia caused by impaired gastrointestinal motility
	Dyspepsia caused by unusual foods or overeating
	Dyspeptic symptoms during pregnancy
	Dyspeptic syndrome
	Dyspeptic disorder
	Gastric dyspepsia
	Delayed gastric emptying
	Slow digestion
	Idiopathic dyspepsia
	Acid dyspepsia
	Upper gastrointestinal motility disorder
	Indigestion
	Nervous dyspepsia
	Non-ulcer dyspepsia
	Feeling of heaviness in the stomach after eating
	Postprandial functional dyspepsia
	Fermentation processes in the intestines
	Stomach upsets
	Gastrointestinal disorders
	Digestive disorders
	Gastrointestinal disorders
	Stomach upset
	Digestive disorder
	Digestive disorders in infants
	Symptoms of dyspepsia
	Putrid dyspepsia syndrome
	Putrefactive dyspepsia syndrome in young children
	Digestive insufficiency syndrome
	Non-ulcer dyspepsia syndrome
	Toxic dyspepsia
	Functional dyspepsia
	Functional digestive disorders
	Chronic dyspepsia
	Chronic episodes of dyspepsia
	Essential dyspepsia

Thank you

The site provides background information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

An overdose of the drug causes a picture similar to acute poisoning: the patient develops problems with the functioning of the digestive system. In addition, rashes appear on the body and mucous membranes of the mouth. The mucous membrane becomes inflamed. The most a clear sign Bismuth poisoning shows dark streaks on the gums. If you regularly use the drug in increased quantities, pathological processes occur in the kidneys, which can no longer be cured.

Treatment for overdose with de-nol involves rinsing the digestive organs. In addition, the patient is given a saline laxative and activated charcoal. It is necessary to take all tests to check the condition of the kidneys, as well as to detect the level of bismuth in the blood. If other symptoms of poisoning appear, measures are taken to alleviate them. If kidney activity is affected, and the bismuth content in the blood is very high, it is necessary to use complexing agents - dimercaptopropanesulfonic and dimercaptosuccinic acids. If severe renal failure develops, hemodialysis is necessary.

Side effects during treatment with de-nol:
Most often, the medicine does not cause any side effects, but some patients experience the following side effects:

• disruption of the digestive system: diarrhea or constipation, vomiting, discoloration of the tongue and feces,
• allergic manifestations: scabies, urticaria, rashes on the body, in isolated cases anaphylactic phenomena.
  If the drug is taken for a very long time or its amount is exceeded, it accumulates in the brain tissue, and this threatens encephalopathy.

All side effects disappear on their own after stopping treatment with de-nol. Before use, you should consult a specialist.

Reviews

There was no pain in the stomach. FGDS revealed Helicobacter pylori+++, superficial gastritis, and active severe inflammation of the gastric mucosa. Peptipak and de-nol were prescribed for 2 weeks. But the instructions say that denol is taken for 4-8 weeks. I've been drinking for almost 5.5 weeks now. When it's 6, I'll finish. There are no side effects. True, I can’t say anything about the effect, since there were no complaints.

Today I left in an ambulance. I’m lying on a drip in the hospital, prednidazole is dripping in a solution. I took Denol for two days, also not trusting the negative reviews, I decided to try the drug on myself. On the second day, in the evening, after taking two tablets, an hour later, slight dizziness began, hot flashes, a taste of salt in the mouth, the face turned red, the jaw muscles tightened, and the gums began to become inflamed and bleed heavily. The doctors said that it was allergic reaction for the drug. So, still, be careful with the drug, similar and. quite common, symptoms occur in different people, it’s worth thinking about.

On the 2nd day of taking Denol, a terrible taste of blood appeared in my mouth, on the 4th day I felt dizzy, my whole body was breaking and something was wrong with my vision, I even lost coordination on the subway... I got very scared and stopped taking the drug

I went through a preoperative medical examination, did a gasteroscopy, found erosion, prescribed terapeft de-nol for 20 days... took it for about a week, no vomiting, no diarrhea, no rash, no headache, none of this happened... Pain appeared in the left side, at first it hurt with back in the area of ​​the kidney, and now it hurts under the ribs, and it hurts so much that it hurts to laugh, sneeze and cough... I’ve already read similar reviews here that the pain goes away when you stop taking it, we’ll see tomorrow...

I am being treated for high acidity and gastritis. I have been using Denol for 28 days, I have 4 more to drink. Used in conjunction with 3 drugs METRANIDOSOL+Omeprozole+Amoxocitlin. I felt great for 3 weeks until I tried a salad with vinegar dressing. Acidity appeared again, and all those weeks I kept a diet of sour foods, sometimes I managed to eat for a year that could cause acidity, but everything was fine, with a course of taking pills, but vinegar brought back the acidity again. and now I have had diarrhea for 3 days. In general, Denol tablets are excellent, but you definitely need to follow a diet and this drug alone is useless in treatment

This is the second day I’ve been taking De-Nol, my mouth is disgusting and bloody. salty taste, the stool is naturally black (the doctor warned me), flatulence. Discharged for 2 weeks 2x2r/day 30 minutes before meals, I’ll try to stand it)

After taking the drug de-nol, I almost died from severe pain in the stomach. A little later, the temperature jumped to 39. I did not immediately connect what happened with taking the medicine. I thought that I had caught the virus. There was no vomiting, no nausea, no diarrhea. But a second dose confirmed everything: severe pain and a temperature of about 40. The stool was black... Please, be careful with the drug!

I took De-Nol together with Clatinol - gastritis with high acidity. Black stool, tongue with a white coating. On the 8th day (without antibiotics) - a metallic sour taste in the mouth, distortion of taste, poor appetite, on the 10th day my stomach began to hurt a little and I feel acid in it. By the way. I drank it 2 tablets. 2 times a day for 30 minutes. before meals

I’ve been taking de Nol for 5 days now... I’m writing a review, it’s 3 o’clock in the morning, I wish I could die from diarrhea :) I can’t understand what kind of medicine it is, why after taking it I have diarrhea, pain and nausea, yesterday I could barely stuff food into myself in the morning. Plus, on the fourth day, my stomach began to pierce everywhere and my right side hurt. Is that how it should be? I'm heading to the doctor.

I took de-nol for 4 days (2 tablets 2 times a day 30 minutes before meals) (I am treating an ulcer and chronic cholecystitis) On the first day I developed terrible headaches, nausea, and weakness. On the 4th day everything got worse and plus terrible diarrhea, I had to cancel. But my stomach really stopped hurting.

I've been drinking for a month so far everything is fine, no pain, no side effects, very happy

I drank 2 tbl de-nol before dinner. In the morning I got up with terrible swelling around my eyes, I had a headache all day, my face was burning and pink, and in the evening I noticed a small red rash on my legs. The medicine is not suitable for everyone, but I think it is effective. The stomach pain has become much less. Now I’m trying to find out how long the side effects last after stopping the drug. What can you drink to relieve unwanted symptoms, especially swelling. Who knows?

Tell me, can an overdose of De Nol cause a child’s body temperature to rise?

They prescribed De-nol 2 times, the first time everything went well, I took it for about a month, the ulcer healed. But after half a year the pain recurred and I was again prescribed De-nol in tandem with antibiotics, I was prescribed to drink it for 8 weeks. On the 7th week of taking it I felt very bad: nausea, night hot flashes, dizziness, weakness in the legs, loss of orientation. I don’t drink It’s been a week now, but the hot flashes at night have not returned to normal, my head is spinning. I don’t know how long it will take until I fully recover. And by the way, my stomach doesn’t hurt!

De Nol. I'm taking it for the second day. .nausea, weakness. It's just a slight lack of coordination that makes him afraid. Take my advice with caution. be sure to consult your doctor.

But they said you can’t do it too much.

Now I've been addicted to de-nol for a week now.
feelings that are incomprehensible, one day the stomach doesn’t hurt, the next it hurts. tingling internal organs here and there this has never happened before.

The chair actually turned black.
no pimples.